Monophosphoryl lipid A (MPL) upregulates major histocompatibility complex (MHC) class I expression by increasing interferon-gamma (IFN-γ)

Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α

This study examined the effect of the pro-inflammatory cytokines interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on the induction of MHC class I-related genes in functionally mature brain neurons derived from cultures of dissociated rat hippocampal tissue. Patch clamp electrophysiology combined with single cell RT-PCR demonstrated that approximately 50% of the untreated...

Major Histocompatibility Complex ( MHC ) Class I Gene Expression in Single Neurons of the Central Nervous System : Differential Regulation by Interferon ( IFN ) - g and Tumor Necrosis Factor ( TNF ) - a

This study examined the effect of the pro-inflammatory cytokines interferong (IFNg ) and tumor necrosis factora (TNFa ) on the induction of MHC class I–related genes in functionally mature brain neurons derived from cultures of dissociated rat hippocampal tissue. Patch clamp electrophysiology combined with single cell RT-PCR demonstrated that z 50% of the untreated neurons contained mRNA for MH...

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell's own translational machinery or that are funneled into the endo-lysosomal vesicular system. The prolonged interaction between a T cell receptor and specific pMHC complexes, after an ex...

Expression of Class I and II Major Histocompatibility Complex (MHC) Antigens in the Developing CNS

Expression of Class I and II Major Histocompatibility Complex (MHC) Antigens in the Developing CNS